结构

times.ttf是一个ttf字体文件，用宋体什么也行。
如下在linux下创建项目:

mkdir 质数方阵
cd 质数方阵
touch maths-number-game.py
mkdir image
cd image
touch temp.gif

如下在windows下创建项目:

mkdir 质数方阵
cd 质数方阵
cd.> maths-number-game.py
mkdir image
cd image
cd.> temp.gif

下包

pip install PySimpleGui
pip install pillow
pip install PyCkin3

代码

import random
import time
import PySimpleGUI as sg
from PyCkin3.tycount3 import TyIsPrime, TyFunctionSquare, TyIsNumber, \
    TyFlatten
from PIL.Image import new
from PIL.ImageDraw import ImageDraw
from PIL.ImageFont import truetype
from tkinter.messagebox import showinfo, showerror, showwarning


gamewidth = 6
square = TyFunctionSquare(random.randint, width=gamewidth, height=gamewidth,
                          a=2, b=100)
numbers = []
for row, i in enumerate(square):
    for column, j in enumerate(i):
        if TyIsPrime(j):
            numbers.append(j)

font = truetype('times.ttf', 25)
color = '#0000ff'
text = '\n'.join('   '.join(str(j) for j in i) for i in square)
image = new(mode='RGB', size=(gamewidth * 55, gamewidth * 40), color=(255, 255, 255))
pen = ImageDraw(image)
pen.text((0, 0), text, font=font, fill=color, direction=None)
image.save('image/temp.gif')

inputs = []
layout = [
    [sg.Image('image/temp.gif')],
    [sg.Text('输入一个数:'), sg.InputText(key='-number-'),
     sg.Button('提交', key='-add-'), sg.Button('删除', key='-del-')],
    [sg.Text('数字:')],
    [sg.Listbox(inputs, key='-numbers-', size=(60, 18))],
    [sg.Submit('提交', key='-submit-')]
]
window = sg.Window('质数方阵', layout)
while True:
    event, values = window.read()
    if event is None:
        break
    elif event == '-add-':
        value = values['-number-']
        if (not TyIsNumber(value)) or ('.' in value):
            showwarning('警告', '输入不是数字')
            continue
        value = int(value)
        if value not in TyFlatten(square):
            showwarning('警告', '输入不在方阵中')
            continue
        inputs.append(value)
        window.find_element('-numbers-').update(inputs)
        window.find_element('-number-').update('')
    elif event == '-del-':
        value = values['-number-']
        if (not TyIsNumber(value)) or ('.' in value):
            showwarning('警告', '输入不是数字')
            continue
        value = int(value)
        if (value not in TyFlatten(square)) or (value not in inputs):
            showwarning('警告', '输入不在方阵中')
            continue
        inputs.remove(value)
        window.find_element('-numbers-').update(inputs)
        window.find_element('-number-').update('')
    elif event == '-submit-':
        print(inputs, numbers)
        if sorted(inputs) == sorted(numbers):
            showinfo('答案正确', '挑战成功')
            break
        else:
            showerror('答案错误', '罚时5秒')
            time.sleep(5.0)
            showinfo('提示', '罚时结束')

window.close()